HANOI, VIETNAM - Media OutReach Newswire - 16 June 2026 - Vietnam Airlines has officially inaugurated its nonstop service between Hanoi and Amsterdam, becoming the first Vietnamese carrier to operate a direct route connecting Vietnam and the Netherlands.

The new service marks a significant milestone in the airline's international network expansion strategy and further strengthens air links between Vietnam and Europe.

The inaugural flight, VN83, departed Noi Bai International Airport at 3:50 AM on June 16, carrying nearly 300 passengers aboard an Airbus A350 wide-body aircraft. After a flight time of more than 12 hours, the aircraft landed at Amsterdam Schiphol Airport. In the opposite direction, flight VN82 departed Amsterdam for Hanoi at 2:00 PM (local time) on the same day.

Vietnam Airlines will operate three round-trip flights per week on Tuesdays, Thursdays and Saturdays using Airbus A350 aircraft. The new route provides a direct air link between the two capitals, while offering passengers greater convenience and seamless onward connectivity across Europe and beyond.

Nguyen Quang Trung, Executive Vice President of Vietnam Airlines, said: "The inauguration of the Hanoi?Amsterdam service reflects Vietnam Airlines' continued commitment to expanding its international network and strengthening Vietnam's connectivity with key global markets. This new route not only offers Vietnamese travellers more convenient access to Europe, but also facilitates greater travel to Vietnam for international visitors. As the national flag carrier, we will continue investing in service excellence and network development to meet evolving customer demand and further reinforce our role as an air bridge linking Vietnam with the world."

Amsterdam serves as a major hub for finance, trade, logistics and commerce in Europe. Through Amsterdam Schiphol Airport, passengers can conveniently access hundreds of destinations across Europe and beyond, further enhancing Vietnam's connectivity with international markets.

The new route also strengthens Vietnam Airlines' presence in Europe. With the addition of Amsterdam, Vietnam Airlines now operates 12 nonstop routes linking Vietnam with eight major European destinations: Paris, London, Frankfurt, Munich, Milan, Copenhagen, Moscow and Amsterdam.

Beyond expanding the airline's network, the new service is expected to support growing trade, investment and tourism flows between Vietnam and the Netherlands, while creating new opportunities for business, cultural and people-to-people exchanges between the two countries.

From 1 July 2026, Vietnam Airlines will increase the frequency of its Hanoi?Moscow service from three to four round-trip flights per week to accommodate growing travel demand between Vietnam and Russia. Together, the launch of the Amsterdam route and the expanded Moscow schedule reflect the airline's ongoing efforts to align capacity with market demand and support Vietnam's increasing integration with the global economy.

The issuer is solely responsible for the content of this announcement.

Hashtags: #VietnamAirlines

MIAMI, June 15, 2026 (GLOBE NEWSWIRE) -- Defiance ETFs today announced the launch of the Defiance Daily Target 2X Short SpaceX ETF (SPCQ), expanding its lineup of single-stock leveraged ETFs designed for active traders seeking amplified exposure to innovative growth companies.

SPCQ is designed for traders seeking magnified, short-term inverse exposure to Space Exploration Technologies Corporation ("SpaceX") (NASDAQ: SPCX), a leading aerospace and satellite communications company that recently completed its initial public offering and is focused on reusable launch systems, commercial space transportation, and global broadband connectivity through its Starlink network.

By seeking to deliver -200% of the daily percentage change in the share price of SpaceX, the Fund allows investors to express tactical bearish views on the company within the accessibility and transparency of an exchange-traded fund.

Investment Objective

The Fund seeks daily inverse investment results, before fees and expenses, of -2 times (-200%) the daily percentage change in the share price of Space Exploration Technologies Corporation (NASDAQ: SPCX). The Fund does not seek to achieve its stated investment objective for a period other than a single trading day.

Underlying Company: Space Exploration Technologies Corporation ("SpaceX")

Space Exploration Technologies Corporation is a company listed on the Nasdaq Stock Market under the ticker SPCX, which recently completed its initial public offering, and that designs, manufactures, and launches advanced rockets and spacecraft. Founded in 2002 by Elon Musk, SpaceX develops and operates launch vehicles for commercial, government, and defense customers, and provides satellite-based broadband services through its Starlink network. The company is a leading participant in the commercial space industry, contributing to the expansion of global satellite communications and orbital launch capabilities.

An investment in the ETF is not a direct investment in SpaceX.

The Fund is not suitable for all investors. The Fund is designed to be utilized only by knowledgeable investors who understand the potential consequences of seeking daily leveraged inverse (-2X) investment results, understand the risks associated with the use of leverage, and are willing to monitor their portfolios frequently. The Fund is not intended to be used by, and is not appropriate for, investors who do not intend to actively monitor and manage their portfolios. The Fund pursues daily leveraged investment objectives, which means it is riskier than alternatives that do not use leverage. The Fund magnifies the inverse performance of the Underlying Security and is designed strictly for short-term use. For periods longer than a single day, the Fund's performance will be the result of compounded daily returns, which is very likely to differ from -200% of the return of SpaceX over the same period. It is possible investors could lose their entire principal within a single trading day.

Media Contact:

Sylvia Jablonski

info@defianceetfs.com

833.333.9383

IMPORTANT DISCLOSURES

Defiance ETFs LLC is the ETF sponsor. The Fund's investment adviser is Tidal Investments, LLC ("Tidal" or the "Adviser").

The Fund's investment objectives, risks, charges, and expenses must be considered carefully before investing. The prospectus and summary prospectus contain this and other important information about the investment company. Please read the prospectus and/or summary prospectus carefully before investing. Hard copies can be requested by calling 833.333.9383.

Investing involves risk. Principal loss is possible. As an ETF, the Fund may trade at a premium or discount to NAV. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the Fund. A portfolio concentrated in a single issuer or sector may be subject to a higher degree of risk. There is no guarantee the Fund's strategy will be properly implemented, and an investor may lose some or all of its investment.

SPCX Price Appreciation Risk. As part of the Fund's inverse investment strategy, the Fund enters into swap agreements and options contracts based on the share price of Space Exploration Technologies Corporation (NASDAQ: SPCX) (the "Underlying Security"). This strategy subjects the Fund to certain of the same risks as if it shorted shares of the Underlying Security, even though it does not. By virtue of the Fund's indirect -2X exposure to changes in the share price of the Underlying Security, the Fund is subject to the risk that the Underlying Security's share price increases. If the share price of the Underlying Security increases, the Fund will likely lose value and, as a result, the Fund may suffer significant losses. The Fund may also be subject to the following risks:

Indirect Investment in SpaceX Risk. SpaceX is not affiliated with the Trust, the Fund, the Adviser, or their respective affiliates, and is not involved with this offering in any way. SpaceX has no obligation to consider the Fund or its shareholders in taking any corporate actions that might affect the value of Fund shares. Investors in the Fund will not have voting rights or other ownership privileges associated with holding shares of SpaceX.

SpaceX Performance Risk. SpaceX may fail to meet publicly announced expectations about its business, launch operations, satellite deployments, or commercial growth initiatives, which could cause the value of the Underlying Security to decline. SpaceX operates in a highly capital-intensive and technologically complex industry where launch failures, manufacturing defects, delays in deployment schedules, or operational disruptions could materially affect its business and financial condition.

Commercial Space Industry Risks. Companies engaged in the commercial space industry operate in an environment characterized by rapid innovation, high development costs, evolving regulatory oversight, and uncertain demand. The success of these businesses depends on their ability to maintain technological competitiveness, execute reliable launches, and secure ongoing funding and customer demand. Increased competition, regulatory changes, launch failures, or reductions in government spending could adversely affect SpaceX and the Fund's performance.

Satellite Communications Industry Risks. Companies involved in satellite communications and broadband services face significant operational, technological, and competitive risks. These businesses require substantial investment in satellite constellations, infrastructure, and network operations, and depend on continued regulatory approval for spectrum access and orbital positioning. Competition from terrestrial broadband providers and other satellite operators may limit growth opportunities and negatively impact the Underlying Security.

Elon Musk Influence Risk. The value of SpaceX may be significantly impacted by the actions, decisions, and public statements of Elon Musk. Public perception regarding Mr. Musk, his leadership, or involvement in other ventures may materially affect investor sentiment and the performance of the Underlying Security.

Single Issuer Risk. Issuer-specific attributes may cause an investment in the Fund to be more volatile than a traditional pooled investment that diversifies risk or tracks the market generally. The Fund's value may fluctuate more sharply in response to events affecting SpaceX than funds that invest in a broader range of issuers.

Recent IPO and Derivatives Capacity Constraints Risk. The Fund's ability to achieve its daily leveraged investment objective depends, in part, on the availability of swaps, options, and other financial instruments that provide exposure to the Underlying Security. For a recently public company, these instruments may be limited, illiquid, costly, or unavailable, particularly shortly after an IPO or during periods of significant volatility or market demand.

Compounding and Market Volatility Risk. The Fund's performance for periods greater than a trading day will be the result of each day's returns compounded over the period, which is likely to differ from 200% of the Underlying Security's performance. During periods of higher volatility, compounding effects may cause the Fund to lose value even if the Underlying Security's share price increases over the longer term.

Daily Correlation/Tracking Risk. There is no guarantee that the Fund will achieve a high degree of leveraged correlation to the Underlying Security. Market disruptions, volatility, or limitations in the availability of derivatives may cause the Fund's performance to deviate from its daily leveraged investment objective.

Leverage Risk. The Fund will seek 2X long exposure through financial instruments, which exposes the Fund to the risk that losses may be magnified. Leverage increases the Fund's volatility, and a relatively small movement in the Underlying Security's share price may result in significant losses for the Fund.

Counterparty Risk. The Fund is subject to counterparty risk due to its use of derivatives. If a counterparty fails to meet its contractual obligations, the Fund may experience delays or losses, which could negatively affect its performance.

Derivatives Risk. The Fund's investments in derivatives may pose risks greater than those associated with directly investing in securities. These risks include increased volatility, imperfect correlation with the Underlying Security, liquidity constraints, valuation challenges, and the potential for losses exceeding the amount initially invested.

Rebalancing Risk. If the Fund is unable to rebalance its portfolio correctly or in a timely manner, its exposure may not be consistent with its investment objective. This may increase the Fund's risk exposure and cause its performance to diverge from its intended daily leveraged results.

Non-Diversification Risk. Because the Fund is non-diversified, it may invest a greater percentage of its assets in a single issuer. As a result, the Fund may be more sensitive to adverse events affecting SpaceX than a diversified fund.

Swap Agreements. The use of swap transactions is a highly specialized activity, which involves investment techniques and risks different from those associated with ordinary portfolio securities transactions.

Fixed Income Securities Risk. When the Fund invests in fixed income securities, the value of your investment in the Fund will fluctuate with changes in interest rates.

High Portfolio Turnover Risk. Daily rebalancing is expected to result in high portfolio turnover. High portfolio turnover may increase transaction costs, which could reduce the Fund's returns and potentially result in higher taxable distributions for shareholders.

Liquidity Risk. Some securities or financial instruments held by the Fund may be difficult to sell, particularly during periods of market stress or volatility. Reduced liquidity may make it difficult for the Fund to adjust its exposure or meet its investment objective.

New Fund Risk. The Fund is a recently organized management investment company with a limited operating history. As a result, there is limited performance history upon which investors can evaluate the Fund.

Distributed by Foreside Fund Services, LLC.

Copyright 2026 GlobeNewswire, Inc.

A great celebration of sport and community, with d'Annunzio University's "sea of blue" among the most visible features of the 26th edition of the Chieti Night Run. The University of Chieti-Pescara took part with 262 entrants, including students and staff, bringing a strong message of wellbeing, community spirit and close ties with the local area to the heart of the city.

Of the Ud'A participants, 202 were students and 60 were members of university staff. Forty-six competed in the official FIDAL 8.7-kilometre race, while 216 opted for the non-competitive 2.9-kilometre run and walk. The figures reflected a broad and diverse presence, combining sport, health, social interaction and a shared sense of belonging.

The event provided one of the most tangible expressions of the "Ud'A Healthy Campus" initiative, through which the University promotes an educational model centred on people and quality of life. For university students facing daily academic demands, examinations and pressure, physical activity represents a valuable ally for both body and mind, helping to improve energy levels, balance, concentration and stress management.

In this context, running and walking alongside the city acquired a meaning that extended beyond the sporting event itself. The strong presence of d'Annunzio University highlighted the institution's commitment to healthy lifestyles, prevention, psychological wellbeing, inclusion and sustainability, in line with the One Health approach underpinning the "Ud'A Healthy Campus" project.

The high level of female participation was also noteworthy, with 110 female students and 35 female members of staff, alongside five international students. These figures reinforced the inclusive nature of the initiative and reflected a university community able to come together beyond the traditional spaces of teaching, research and work.

"The response from d'Annunzio University was extraordinary," said the University's Director General, Paolo Esposito. "The remarkable presence of more than 200 students once again demonstrated the close relationship between the University and the city, as well as our commitment to promoting physical activity and sport as tools for wellbeing, inclusion and social cohesion. All this forms part of the broader 'Ud'A Healthy Campus' project, which translates the One Health concept into concrete actions aimed at promoting healthy lifestyles, physical and psychological wellbeing, balanced nutrition and sustainability."

The CARES Centre - the University's Centre for Disability, Rehabilitation and Sports Medicine, directed by Professor Domenico Genovesi - also took part in the event. Supported by Chieti Municipal Pharmacies, the Centre set up information points dedicated to prevention and wellbeing.

From a sporting perspective, the 8.7-kilometre competitive race started from Chieti's Villa Comunale and attracted 360 runners to the start line. Stefano Massimi claimed victory in 26:19, ahead of Lorenzo Dell'Orefice, who finished second in 27:11, while Nunzio Gabriele secured third place in 27:54.

In the women's race, Melissa Palanza took victory and finished thirteenth overall in 31:13. Alessia Righetti placed second and fifteenth overall in 31:25, while Sara Di Prinzio completed the podium in fortieth place overall with a time of 34:17.

Five athletes from d'Annunzio University finished on the podium at the event. The overall men's and women's titles went to Luca Tollis and Alessia Tartaglia. Among members of the University's Recreational and Cultural Association (CRAD Ud'A), Francesco Cavallucci and Lorena Savini were the top male and female finishers respectively.

Francesco D'Agostino narrowly missed the podium, securing an excellent fourth place overall.

In recognition of the University's strong involvement in the event, commemorative awards were presented by Piero Perrucci, of US Acli Marathon Chieti, to Paolo Esposito, Director General of the University, and Tiziano Zuccarini, President of CRAD Ud'A.

d'Annunzio University's "sea of blue"

Copyright 2026 GlobeNewswire, Inc.

MIAMI, June 15, 2026 (GLOBE NEWSWIRE) -- Defiance ETFs, a leader in thematic and leveraged exchange-traded funds, today announced that Cboe BZX Exchange, Inc. (the "Exchange") has authorized the resumption of trading in shares of the Defiance Daily 2X Space ETF (Cboe BZX: SPCL), following the temporary trading halt initiated by the Exchange on June 12, 2026.

The temporary halt was the result of the Exchange exercising its broad discretionary authority to halt trading in a listed ETF, as authorized by Exchange rules. The Exchange has now exercised that same authority to lift the halt and permit trading in SPCL shares to resume.

Upon resumption, shares of SPCL may again be bought and sold on the secondary market during regular market hours. Throughout the temporary halt, the underlying portfolio assets remained secure and were not impacted by the halt of trading initiated by the Exchange.

For real-time updates on the status of SPCL, please monitor the Exchange's Issuer Portal (SPCL) or contact your financial advisor.

For full fund details, the prospectus, holdings, and performance current to the most recent month-end, visit defianceetfs.com/spcl or call 833.333.9383.

An investment in SPCL is not a direct investment in the underlying securities. The Fund is not suitable for all investors. The Fund is designed to be utilized only by knowledgeable investors who understand the potential consequences of seeking daily leveraged (2X) investment results, understand the risks associated with the use of leverage, and are willing to monitor their portfolios frequently. The Fund is not intended to be used by, and is not appropriate for, investors who do not intend to actively monitor and manage their portfolios. The Fund pursues daily leveraged investment objectives, which means it is riskier than alternatives that do not use leverage. The Fund magnifies the performance of the Target Portfolio and is designed strictly for short-term use. For periods longer than a single day, the Fund's performance will be the result of compounded daily returns, which is very likely to differ from 200% of the return of the Target Portfolio over the same period. It is possible that investors could lose their entire principal within a single trading day.

Important Disclosures

Defiance ETFs LLC is the ETF sponsor. The Fund's investment adviser is Tidal Investments LLC ("Tidal" or the "Adviser").

The Fund's investment objectives, risks, charges, and expenses must be considered carefully before investing. The prospectus and summary prospectus contain this and other important information and can be obtained by calling 833.333.9383 or by visiting defianceetfs.com/spcl. Please read the prospectus and summary prospectus carefully before investing.

An investment in the Fund involves a high degree of risk. An investor could lose the full principal value of his or her investment within a single day.

Strategy and Reconstitution Risk. The Fund is actively managed and, per its recently amended Prospectus, may reconstitute its portfolio to consist of exposure to a single Space Company security in response to a "Material Space Event" ? defined to include an initial public offering of a company, such as SpaceX, which the Adviser determines to be a significant participant in the space economy. SpaceX's IPO, a Material Space Event, will result in the Fund holding all or a predominant portion of its portfolio in instruments providing exposure to SpaceX shares, subjecting existing and future Shareholders to a substantially more concentrated and potentially more volatile investment portfolio due to such an event. Fund investment results following a reconstitution in response to a Material Space Event may differ materially from prior results and the Fund may as a result temporarily deviate from its daily targeted exposure level. The Fund's prospectus does not require the Adviser to provide advance notice before a reconstitution; however, the Fund's Target Portfolio is published daily on its website at www.defianceetfs.com/spcl.

An investment in the Fund is not an investment in SpaceX. The Fund seeks to obtain exposure to SpaceX Class A common stock, and to other Space Company securities, through derivatives, not by holding the underlying securities directly. Fund holdings are subject to change at any time and should not be considered a recommendation to buy or sell any security.

Focused Portfolio and Concentration Risk. The Fund may seek exposure to one or a limited number of Space Company securities, including SpaceX. Given the Fund's exposure is concentrated in a one or a limited number of underlying stocks, such as SpaceX, the Fund is subject to the price movements, business results, regulatory developments, and other risks specific to SpaceX or other Space Companies. The Fund is significantly less diversified than traditional ETFs, and its performance is more volatile than a fund seeking exposure to a broader market sector or seeking to track a broad-based securities index.

Leverage, Compounding and Daily Reset Risk. The Fund seeks daily investment results equal to 200% of the daily performance of a Target Portfolio consisting of one or a limited number of Space Company securities, which may include or consistent entirely of SpaceX Class A common stock due to the Material Space Event. The Fund obtains exposure in excess of its net assets through leverage, which magnifies both gains and losses. The Fund's returns over periods longer than a single day will likely differ, in amount and possibly direction, from its stated daily target. For periods longer than a single day, the Fund will lose money if its Target Portfolio performance is flat, and it is possible that the Fund will lose money even if its Target Portfolio's performance increases. The Fund is intended for short-term use and is not appropriate for investors who do not intend to actively monitor and manage their portfolios.

Newly Public Company Risk. SpaceX has recently completed, or is in the process of completing, its initial public offering. The first day of trading in a newly public company's securities frequently involves extraordinary market activity and may differ significantly from subsequent trading days. For example, trading in SpaceX common stock may be characterized by substantial price volatility, rapid price movements, significant differences between the IPO price and the opening market price, wide bid-ask spreads, trading imbalances, limited liquidity, trading halts, and other market disruptions. These conditions may make it difficult for market participants to value SpaceX common stock and may contribute to significant fluctuations in the market price of the Fund's Shares.

SpaceX-Specific Risks. The Fund's exposure to SpaceX stock will subject it to risks specific to SpaceX, including its expected status as a controlled company with voting power concentrated in founder Elon Musk through Class B common stock (10 votes per share), the Fund's dependence on Mr. Musk's services and reputation, and the execution risk associated with unproven or novel technologies such as the Starship program, next-generation Starlink satellites, and orbital AI initiatives.

Initial Trading Day IPO Exposure Risk. The Fund expects to seek exposure to the performance of SpaceX common stock measured from the opening market price of SpaceX common stock on its first day of exchange trading. The Fund will not seek to provide exposure to the difference between the IPO offering price and the opening market price of SpaceX common stock. There can be no assurance that the Fund will be able to obtain, maintain, or rebalance its desired level of exposure to the performance of SpaceX common stock during its in initial day of trading.

Derivatives Capacity Constraints Risk. Because SpaceX will be a newly public company, the markets for swap agreements, options contracts, and other instruments that the Fund may use to obtain leveraged exposure may be limited, illiquid, volatile, costly, or unavailable. Counterparties may impose exposure limits, exchanges may impose position limits or other restrictions, and market participants may be unwilling or unable to provide the Fund with the desired level of exposure. These constraints may increase tracking error, cause the Fund to return substantially less than its desired daily leveraged exposure to the performance of SpaceX stock, or prevent the Fund from achieving its investment objective. These risks may be particularly pronounced during the period immediately following an IPO, when trading volumes, liquidity conditions, derivatives availability, counterparty capacity, price discovery, and market volatility may be highly uncertain.

Derivatives and Non-Diversification Risk. The Fund uses swap agreements and/or listed options contracts to obtain economic exposure to its Target Portfolio securities, which are subject to counterparty, liquidity, valuation, correlation, and leverage risks, as well as the risk that a derivative will not perform as expected. The Fund is classified as non-diversified and may invest a larger portion of its assets providing exposure to a single issuer.

Tax Risk. The Fund's use of swaps and other derivatives may produce taxable income, including ordinary income and short-term capital gains, which are generally taxable at higher rates than long-term capital gains.

Past performance does not guarantee future results. Fund holdings and exposures are subject to change at any time and should not be considered recommendations to buy or sell any security.

Defiance Daily 2X Space ETF is distributed by Foreside Fund Services, LLC.

About Defiance ETFs

Founded in 2018, Defiance is a leading ETF issuer specializing in thematic, income, and leveraged ETFs. Our first-mover leveraged single-stock ETFs empower investors to take amplified positions in high-growth companies, providing precise leverage exposure without the need to open a margin account.

Media Contact: Brenda Hentschel | bhentschel@gregoryagency.com | 201.705.3758

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/5a5c0544-ce9e-448b-8fc2-3ed279f10583

Copyright ? 2026 GlobeNewswire, Inc.

IRVINE, Calif., June 15, 2026 (GLOBE NEWSWIRE) -- CEO iHerb, Emun Zabihi, dinobatkan sebagai pemenang EY US Entrepreneur Of The Year 2026 Pacific Southwest Award. Zabihi dipilih di antara hampir 1.000 peserta program yang mencakup 592 finalis dari 17 wilayah yang bersaing memperebutkan gelar tersebut.

Sejak menjadi CEO di tahun 2021, Zabihi telah memimpin iHerb melalui periode ekspansi internasional dan inovasi yang signifikan. Sekarang, iHerb melayani jutaan pelanggan di seluruh dunia melalui jaringan eCommerce dan pemenuhan pesanan global canggih, yang dibangun atas dasar keaslian produk, transparansi, dan kepercayaan pelanggan. Di bawah kepemimpinan Zabihi, perusahaan telah memperkuat posisinya sebagai platform eCommerce kebugaran global yang didedikasikan untuk membantu konsumen mendapatkan produk kesehatan dan kebugaran berkualitas tinggi di mana pun mereka tinggal.

"Pengakuan ini merupakan bukti nyata atas dedikasi luar biasa para anggota tim yang mewujudkan misi kami setiap hari," kata Zabihi. "Seiring dengan terus meningkatnya permintaan konsumen akan produk kesehatan dan kebugaran secara global, kami tetap berfokus pada inovasi, kepercayaan pelanggan, dan menghadirkan pengalaman luar biasa yang membantu masyarakat menjalani hidup sehat."

Kini memasuki tahun ke-41, program Entrepreneur Of The Year memberikan penghargaan kepada para pemimpin bisnis atas kecerdikan, keberanian, dan semangat kewirausahaan mereka. Program ini menghargai para pendiri yang merintis bisnis mereka dari awal dengan modal sendiri atau menggalang modal dari luar untuk mengembangkan perusahaan mereka. Penghargaan ini juga ditujukan bagi para CEO transformasional yang menanamkan inovasi ke dalam organisasi yang sudah ada untuk mendorong pertumbuhannya. Selain itu, program ini menghargai para pemimpin bisnis keluarga lintas generasi yang merancang ulang model bisnis lama untuk memperkuatnya demi masa depan.

Para pemenang tingkat regional dipilih oleh panel independen yang terdiri dari para pemenang terdahulu, CEO terkemuka, dan para pemimpin bisnis. Para juri menilai para kandidat berdasarkan penciptaan nilai jangka panjang, semangat kewirausahaan, komitmen yang berorientasi pada tujuan, serta pertumbuhan dan dampak yang signifikan.

Sebagai pemenang penghargaan Pacific Southwest, Zabihi kini akan dipertimbangkan oleh para juri nasional untuk Entrepreneur Of The Year 2026 National Awards. Penghargaan tingkat nasional ini akan diberikan pada bulan November dalam acara tahunan Strategic Growth Forum?. Acara tersebut menjadi tempat berkumpulnya para CEO perusahaan dengan pertumbuhan tinggi, eksekutif Fortune 1000, dan investor untuk membentuk masa depan dunia bisnis.

Tentang Entrepreneur Of The Year

Didirikan pada tahun 1986, Entrepreneur Of The Year telah memberikan penghargaan kepada lebih dari 11.000 visioner ambisius dalam memimpin bisnis yang sukses dan dinamis di AS. Sejak itu, program ini telah berkembang ke hampir 60 negara serta kawasan di seluruh dunia.

Tentang iHerb, LLC

iHerb adalah salah satu peritel eCommerce terbesar di dunia dengan spesialisasi di bidang kesehatan dan kebugaran, menghadirkan produk dari sekitar 2.000 merek kepada lebih dari 15 juta pelanggan aktif di 180 negara. Didukung oleh tenaga kerja global yang berjumlah hampir 2.000 anggota tim, iHerb memadukan skala global dengan pengalaman yang sangat terlokalisasi, menawarkan layanan dalam 36 bahasa, lebih dari 80 mata uang, dan lebih dari 40 metode pembayaran lokal. Jaringan rantai pasokan global iHerb yang canggih didukung oleh sembilan pusat pemenuhan pesanan berkendali suhu yang tersebar di AS, Asia, dan Timur Tengah. Hal ini memberikan pelanggan pengalaman berbelanja yang mulus dan andal. iHerb, yang didirikan pada tahun 1996 dan berkantor pusat di Irvine, California, memiliki misi untuk membuat kesehatan dan kesejahteraan menyeluruh dapat diakses oleh semua orang. Untuk mendapatkan informasi selengkapnya, kunjungi corporate.iherb.com.

Untuk mengajukan pertanyaan media, silakan hubungi:

press@iherb.com

Copyright 2026 GlobeNewswire, Inc.

Since becoming CEO in 2021, Zabihi has led iHerb through a period of significant international expansion and innovation. Today, iHerb serves millions of customers worldwide through a sophisticated global eCommerce and fulfillment network built on product authenticity, transparency and customer trust. Under Zabihi's leadership, the company has strengthened its position as a global wellness eCommerce platform dedicated to helping consumers access high-quality health and wellness products wherever they live.

"This recognition is a testament to the remarkable team members who bring our mission to life every day," said Zabihi. "As consumer demand for health and wellness continues to grow globally, we remain focused on innovation, customer trust and delivering exceptional experiences that help people live healthy lives."

Now in its 41st year, the Entrepreneur Of The Year program honors business leaders for their ingenuity, courage and entrepreneurial spirit. It celebrates original founders who bootstrapped their business from inception or raised outside capital to grow their company, transformational CEOs who infused innovation into an existing organization to catapult its trajectory and multigenerational family business leaders who reimagined a legacy business model to strengthen it for the future.

Regional winners were chosen by an independent panel of past winners, top CEOs and business leaders. Judges assessed candidates on long-term value creation, entrepreneurial spirit, purpose-driven commitment, and significant growth and impact.

As a Pacific Southwest award winner, Zabihi will now be considered by the national judges for the Entrepreneur Of The Year 2026 National Awards, which will be presented in November at the annual Strategic Growth Forum, where high-growth CEOs, Fortune 1000 executives and investors converge to shape the future of business.

About Entrepreneur Of The Year

Founded in 1986, Entrepreneur Of The Year? has celebrated more than 11,000 ambitious visionaries who are leading successful, dynamic businesses in the US, and it has since expanded to nearly 60 countries and territories globally.

About iHerb, LLC

iHerb is one of the world's largest eCommerce retailers specializing in health and wellness, delivering products from approximately 2,000 brands to over 15 million active customers across 180 countries. Supported by a global workforce of nearly 2,000 team members, iHerb combines global scale with a deeply localized experience, offering service in 36 languages, over 80 currencies, and more than 40 local payment methods. iHerb's sophisticated global supply chain network spans nine climate-controlled fulfillment centers located in the U.S., Asia and the Middle East, providing customers a seamless and reliable shopping experience. Founded in 1996 and based in Irvine, California, iHerb is on a mission to make health and wellness accessible to all. For more information, please visit corporate.iherb.com.

For media inquiries, please contact:

press@iherb.com

Copyright 2026 GlobeNewswire, Inc.

New hybrid engine triples the industry's average fidelity score while cutting false positives by 60%

PARAMUS, N.J., June 15, 2026 (GLOBE NEWSWIRE) -- Checkmarx, the global leader in agentic application security, today announced a major advancement to the Checkmarx One platform: a new hybrid static application security testing (SAST) scanning engine set to deliver the industry's highest fidelity, known in the industry as an F1 score. AI-accelerated development is driving an unprecedented surge in software vulnerabilities, leaving organizations facing a tsunami of risk that no single scanning approach can address alone.

Neither rules-based analysis nor AI models tell the whole story alone. Deterministic scanning is the precision standard for the languages it covers, but AI-assisted development has introduced new and emerging languages that fall outside any fixed rule set. AI extends coverage to that new ground. However, scanning at volume surfaces findings faster than teams can act on them, burying the vulnerabilities that matter in noise. Today, 49% of code in production is AI generated and measurably more insecure, and exploit windows collapsing from months to minutes. Organizations need both the precision of deterministic analysis and the reach of AI.

To meet this moment, Checkmarx is introducing a new next generation SAST hybrid scanning engine within Checkmarx One. It combines three layers of protection: a deterministic rules-based foundation refined over two decades of enterprise AppSec; a purpose-tuned LLM engine that extends that proven foundation to any language, including AI-generated code and emerging languages; and the new Finding Analysis Engine (FAE), which confirms true positives and suppresses false ones before a single finding reaches a developer.

"No single approach - rules-based or AI - tells the whole story on its own," said Sandeep Johri, CEO of Checkmarx. "Deterministic scanning has earned its place as the precision standard, and AI extends that reach to code the rules were never written for. But neither alone separates the findings that matter from the ones that don't. At today's volumes, that noise is what slows teams down and drives up cost. Checkmarx One's hybrid engines bring together the best of both in a fundamentally different architecture."

In head-to-head testing across seven real production codebases, Checkmarx One's hybrid engine achieved an F1 score of 0.64 ? more than three times the 0.20 average across competing approaches that Checkmarx evaluated - while reducing false positives by 60%. The result: teams cut through massive findings volumes to high-confidence signals, focus remediation on what is genuinely exploitable, and stay protected as AI-generated code keeps introducing new risk.

Key capabilities of the new Checkmarx One hybrid scanning engine include:

Finding Analysis Engine (FAE): Reasons over every raw finding, suppressing false positives and confirming true ones - turning raw signals into high-fidelity results teams can act on immediately.

Language-agnostic scanning: Extends proven detection to any language, including AI-generated code, emerging languages, and polyglot codebases (applications that combine multiple programming languages) - closing the new gaps that AI coding assistants introduce without sacrificing precision on established ones.

Defensible governance: Board-grade evidence of what is exploitable and what has been resolved, anchored to real attackability rather than raw counts - so leaders can make risk decisions.

"AI has handed developers an unprecedented productivity boost, but independent benchmarks show that even the best models produce insecure code in a third to nearly half of cases - and the tools meant to catch it can burn through compute budgets chasing false positives," said Jonathan Rende, Chief Product Officer at Checkmarx. "What teams need isn't just more findings, it's confidence and predictability: surfacing the vulnerabilities that truly matter, eliminating the noise, and doing it without blowing past budgets. That's the assurance Checkmarx One now gives every customer - the highest fidelity in the industry, with the economics to match."

The new hybrid scanning engines and Finding Analysis Engine are available in early access now as part of the Checkmarx One platform. For more information, visit checkmarx.com or join the upcoming virtual summit Agentic AppSec Unleashed '26 on June 16, 2026.

About Checkmarx

Checkmarx is the leader in agentic application security, delivering enterprise-grade protection while lowering engineering costs and accelerating development velocity. The Checkmarx One platform scans trillions of lines of code each year for companies, cutting vulnerability density by more than half. Its autonomous security agents detect and counter AI-driven threats across the SDLC, providing prevention-first protection for legacy, modern, and AI-generated code at enterprise scale. Follow Checkmarx on LinkedIn, YouTube, and X.

For more information:

PR@checkmarx.com

Copyright 2026 GlobeNewswire, Inc.

Milestone advances General Fusion toward the final stages of becoming the first publicly traded pure-play fusion energy company

VANCOUVER, British Columbia, June 15, 2026 (GLOBE NEWSWIRE) -- General Fusion Inc. ("General Fusion" or the "Company"), a leader in the global race to commercialize fusion energy, today announced that its joint registration statement on Form F-4, as amended (the "Registration Statement"), filed in connection with its proposed business combination with Spring Valley Acquisition Corp. III (NASDAQ: SVAC), a publicly traded special purpose acquisition company ("Spring Valley," or "SVAC"), was declared effective by the Securities and Exchange Commission on June 12, 2026.

Spring Valley has set a record date of June 12, 2026 (the "Record Date"), and meeting date of July 6, 2026, for its extraordinary general meeting of shareholders ("Extraordinary General Meeting"). Spring Valley shareholders of record at the close of business on the Record Date are entitled to receive notice of the Extraordinary General Meeting and to vote the ordinary shares of Spring Valley owned by them at the Extraordinary General Meeting. The Extraordinary General Meeting will be held in-person at the offices of Greenberg Traurig, LLP, located at One Vanderbilt Ave, New York, NY 10017. If the Spring Valley and General Fusion securityholders vote to approve the proposed business combination, the transaction is expected to close shortly thereafter, subject to the satisfaction of customary closing conditions.

General Fusion previously announced its proposed business combination with Spring Valley on January 22, 2026. At the closing of the transaction, Spring Valley will be renamed "General Fusion Group Ltd.," and once the transaction is completed, the combined company's shares and warrants are expected to trade on Nasdaq under the ticker symbols "GFUZ" and "GFUZW," respectively, subject to approval of its listing application.

General Fusion continues to advance its core technology while building momentum across governance, global industry engagement, and capital markets:

Real machines, real results: Over the past two decades, General Fusion has built and operated dozens of real-world testbeds, prototypes, and demonstrations, completing more than 200,000 plasma experiments. This work has culminated in Lawson Machine 26 ("LM26"), the Company's world-first, large-scale Magnetized Target Fusion ("MTF") demonstration machine, now operating at its Vancouver facility. General Fusion is one of four companies worldwide to have achieved and published meaningful fusion results on the path to the Lawson criterion, supported by more than 35 peer-reviewed publications and 210 issued and pending patents. Recent publications supporting General Fusion's MTF technology include papers on a key LM26 temperature diagnostic, as well as U.S. Department of Energy-funded research conducted by Savannah River National Laboratory that supports the Company's advantageous fuel-cycle design for MTF using its proprietary liquid metal wall.

Award-winning innovation: General Fusion was recently ranked first on TIME's prestigious list of the World's Top GreenTech Companies of 2026 for its leadership in fusion energy. The Company was also named one of Canada's Most Ambitious Companies by BetaKit.

Experienced leadership team: Building on General Fusion's seasoned leadership, the Company announced key appointments to strengthen its Board of Directors as it prepares to enter the U.S. public markets. Wendy Kei, Board Chair of Ontario Power Generation, will serve as Audit Committee Chair, and Thomas Boehlert, former CFO of US Strategic Metals, with more than three decades of experience across industrials, natural resources, agribusiness, power generation, and the energy transition, will serve as Chair of the Nominating and Governance Committee.

Global presence across fusion, energy, technology, and investor conferences: In the first half of 2026, General Fusion leadership presented at major industry events, including FusionX:Global, FusionX:Americas, the Fusion Industry Association Annual Policy Conference, The Economist's Fusion Fest, Web Summit Vancouver, and Canaccord Genuity's inaugural Nuclear Nexus conference. On April 29, the Company hosted an Analyst Day at Nasdaq MarketSite in New York, with more than 100 attendees participating in person and online, reflecting strong engagement from the investment community.

Quick Facts:

General Fusion's MTF is designed to solve significant barriers to commercializing fusion energy at a time when electricity demand is surging, and nations around the world are racing to commercialize fusion power.

As a technology, MTF aims to achieve fusion in a practical way, avoiding superconducting magnets and high-powered lasers, while enabling the use of existing materials for durable machines that would produce cost-effective energy.

In early 2025, General Fusion announced that it had designed, built, and begun operating its world-first LM26 fusion demonstration machine in under two years. LM26 is the first MTF demonstration machine to be built at a commercially relevant scale. It mechanically compresses plasma with a lithium liner at 50% commercial-scale diameter.

LM26 aims to achieve key fusion technical milestones: plasma heating to 1 keV (10 million degrees Celsius), then 10 keV (100 million degrees Celsius), and ultimately the Lawson criterion, the combination of fusion parameters that can produce net fusion energy in the plasma.

About General Fusion

General Fusion is pursuing a fast and practical approach to commercial fusion energy and is headquartered in Vancouver, Canada. The Company was established in 2002 and has been funded by a global syndicate of leading energy venture capital firms, industry leaders, and technology pioneers. Learn more at www.generalfusion.com. General Fusion announced its proposed business combination with Spring Valley in January 2026.

Investor Relations Contact:

You can contact General Fusion's Investor Relations team by email at: investors@generalfusion.com.

If you are based in North America, you may also leave a toll-free voicemail at +1 (833) 717-1519. Callers outside North America can reach us at +1 (236) 253-6968.

Media Relations Contact:

media@generalfusion.com

1-866-904-0995

Copyright 2026 GlobeNewswire, Inc.

LIDK?PING, Sweden, June 15, 2026 (GLOBE NEWSWIRE) -- ASKO is proud to be an official partner and refrigerator sponsor of the FIFA World Cup 2026, reflecting our global presence and commitment to excellence. This collaboration brings together two worlds driven by precision, performance and consistency - where every detail matters.

Rooted in Scandinavian design and a legacy of innovation, ASKO appliances are built to deliver long-lasting performance, reliability and uncompromising quality. The partnership highlights a shared mindset: the discipline, dedication and pursuit of perfection required to perform at the highest level.

ASKO's campaign celebrates the time, patience and dedication it takes to become a champion. It's a journey that often begins with childhood dreams of the future. Just as great athletes are shaped over years of practice and persistence, ASKO appliances are developed with the same long-term perspective. Built for longevity, reliability and enduring performance, they reflect a commitment to quality that stands the test of time - from early inspiration to lasting excellence.

ASKO is proud to be an official partner and refrigerator sponsor of the FIFA World Cup 2026.

From stadium performance to everyday living

On the global stage, performance is everything. The same principles that define elite sport are at the core of ASKO's approach to appliance design. Every ASKO refrigerator is engineered to preserve freshness, optimise storage and deliver consistent results ? day after day.

About ASKO

ASKO is rooted in Scandinavian design values of simplicity, durability, and functionality. Today, it creates premium kitchen and laundry appliances that unite precision engineering with timeless design?built to endure and thoughtfully enhance everyday living.

For more information, visit www.asko.com or contact press@asko.com. 

Copyright 2026 GlobeNewswire, Inc.

BONN, Germany, June 15, 2026 (GLOBE NEWSWIRE) -- Mavenir, the software company building Cloud-Native, AI-by-design mobile networks, today announced to be the first tier-1 telecommunications infrastructure software provider to receive the BSI NESAS certification for a 5G Packet Core network function. The certificate confirms that the Mavenir Network Repository Function (NRF) fulfils the security standard requirements for use as a critical component in public telecommunications networks in Germany.

Fabian Hodouschek, Head of Certification at the Federal Office for Information Security (BSI), presents the BSI NESAS certificate to Omar Shahdad

Fabian Hodouschek, Head of Certification, Federal Office for Information Security (BSI): "By issuing the first BSI NESAS cybersecurity certificate to the manufacturer Mavenir, we make an important contribution to securing Germany's mobile telecom networks. It is the first certificate for a critical 5G core network component used by operators of public 5G mobile networks in Germany. It confirms that Mavenir's Network Repository Function, including its development and lifecycle processes, meets the standards of the internationally recognized NESAS security framework. We congratulate Mavenir on this success and welcome the commitment of manufacturers to have their critical core network components certified according to BSI NESAS."

This initial milestone positions Mavenir at the forefront of regulatory readiness following Germany's mandatory BSI NESAS certification requirements that took effect on January 1, 2026, under the German Telecommunications Act (TKG) and the BSI Act (BSIG). Mavenir is progressing certification of its full Packet Core and IMS portfolio, with completion targeted by Q3 2026, enabling operators to deploy compliant, secure, and cloud-native network architectures at scale.

Omar Shahdad, Senior Vice President, Operations, Mavenir: "This certification validates Mavenir's commitment to delivering not only industry-leading 5G software, but software that meets the most rigorous national cybersecurity standards. As regulators across Europe raise the bar for network security, Mavenir is ready."

The certificate was awarded by the certification body of the Federal Office for Information Security (BSI) of Germany under the BSI NESAS certification scheme, a cybersecurity certification that builds upon the internationally recognized GSMA NESAS security assurance framework. BSI NESAS combines rigorous assessment of product development and lifecycle processes with hands-on security testing of the actual product, setting a high bar for critical network infrastructure.

The BSI NESAS certificate for Mavenir NRF CC 24.4.2 p4 is publicly available on the BSI website: https://www.bsi.bund.de/SharedDocs/Zertifikate_NESAS/NESAS-0007-2026.html?nn=1078814

For more information about the BSI NESAS certification scheme, visit: https://www.bsi.bund.de/dok/nesas-en

About Mavenir

Mavenir is enabling intelligent, automated, programmable networks through the development of telco-first, cloud-native, AI-by-design software solutions for mobile operators. The company's deep telco domain expertise has been proven through deployments with 300+ operators globally in over 120 countries, which together serve more than 50% of the world's subscribers. Mavenir combines its deep telco experience with the cloud and IT expertise and data science skillsets essential to solving real customer challenges. Its proven software solutions are AI by design, delivering the AI-native future and operators' evolution to TechCos. ​For more information, please visit www.mavenir.com

Mavenir PR Contact:

Emmanuela Spiteri

PR@mavenir.com

Copyright 2026 GlobeNewswire, Inc.

RUEIL-MALMAISON, France and TAIPEI, Taiwan, June 15, 2026 (GLOBE NEWSWIRE) -- Schneider Electric, a global energy technology leader, today announced a strategic collaboration with Hon Hai Technology Group (Foxconn), the world's largest electronics manufacturer, to help define and scale the next generation of AI data centers.

As AI adoption surges, the demands on digital infrastructure are being fundamentally reshaped. This collaboration brings together Foxconn's unmatched expertise in advanced compute platforms, AI rack integration, and global manufacturing with Schneider Electric's leadership in power systems, cooling, and energy management. Together, the companies aim to deliver integrated, ready-to-deploy solutions that enable customers to build and operate AI infrastructure with greater speed, efficiency, and predictability across regions. Production will begin later this year.

"At the pace AI is evolving, the industry requires a new model for how infrastructure is designed, built, and delivered," said Young Liu, Chairman of Foxconn. "By combining Foxconn's strength in AI systems and global manufacturing with Schneider Electric's deep expertise in power and energy, we are creating a path for customers to deploy AI capacity at scale?faster, smarter, and more sustainably."

"AI demand continues to accelerate, and as compute scales to keep pace, the energy behind it becomes a fundamental enabler," said Olivier Blum, CEO of Schneider Electric. "If we want to scale AI responsibly, these systems must be connected. This is where energy intelligence becomes essential. At Schneider Electric, we are advancing energy tech to build the most efficient and sustainable AI factories by bringing integrated power, cooling, and digital capabilities into AI data centers. Working with Foxconn, we are helping customers build capacity with real speed, resilience, and efficiency, as energy technology partners to an industry that is firmly entering the era of intelligence."

Through this collaboration, Foxconn and Schneider Electric will co-develop next-generation reference architectures for AI data centers. The partnership will also explore innovations in closed-loop energy optimization, modular power and cooling skids, and standardized design frameworks, creating repeatable, high-performance blueprints for AI factories worldwide. By aligning manufacturing excellence with energy intelligence, the two companies are setting the foundation for a new class of AI infrastructure that is scalable by design, efficient by default, and ready to meet the accelerating demands of the AI era.

Schneider Electric and Hon Hai Technology Group (Foxconn) announce strategic collaboration to accelerate next-generation AI data centers

Press contact: media.relations@se.com

About Foxconn

Hon Hai Technology Group (Foxconn) (TWSE:2317) is the world's largest electronics manufacturer and leading technology solutions provider, ranking 28th in Fortune Global 500. In 2025, revenue totaled TWD8.1 trillion (approx. USD260 billion). The Group's market share in electronics manufacturing services (EMS) exceeds 40% and covers four major product segments: smart consumer electronics; cloud and networking; computing; and components and other. Operating over 240 campuses across 24 countries, Foxconn is one of the world's largest employers with approx. 900,000 employees during peak manufacturing season. We are committed to sustainability in the manufacturing process and serving as a best-practice model for global enterprises. The Group is guided by its 3+3+3 strategy, actively investing in industries of electric vehicles, digital health, and robotics; in technologies of artificial intelligence, semiconductors and next-generation communications; in intelligent platforms of Smart Manufacturing, Smart EV and Smart City. Foxconn is dedicated to becoming a comprehensive, world-class enterprise, with AI as its core driving force. Learn more at www.foxconn.com/en-us

About Schneider Electric

Schneider Electric is a global energy technology leader, driving efficiency and sustainability by electrifying, automating, and digitalizing industries, businesses, and homes. Its technologies enable buildings, data centers, factories, infrastructure, and grids to operate as open, interconnected ecosystems, enhancing performance, resilience, and sustainability. The portfolio includes intelligent devices, software-defined architectures, AI-powered systems, digital services, and expert advisory.

With 160,000 employees and one million partners in over 100 countries, Schneider Electric is consistently ranked among the world's most sustainable companies.

www.se.com

Discover the newest perspectives on Advancing Energy Tech on Schneider Electric Insights.

Copyright 2026 GlobeNewswire, Inc.

Service provides medical assessment, ingredient information and delivery arrangements where appropriate

HONG KONG SAR - Media OutReach Newswire - 15 June 2026 - FastMed today announced the launch of online consultation support for hair loss concerns, providing a private and structured pathway for medical assessment of increased shedding, a receding hairline, thinning at the crown and reduced hair volume. The service covers online information submission, doctor assessment, review of possible hair loss causes, evidence-informed ingredient information and follow-up arrangements where appropriate.

Structured Online Assessment for Hair Loss Concerns

Hair loss has become an earlier concern among urban adults. Many cases are first managed through over-the-counter shampoos, hair growth serums, supplements or products promoted online. Hair loss, however, may be associated with a range of factors, including genetics, hormonal changes, stress, lack of sleep, nutritional status, scalp conditions, underlying illnesses and medication-related effects.

FastMed's online consultation workflow supports the submission of relevant health information before medical assessment. Information reviewed may include duration of shedding, location of hair thinning, family history of hair loss, recent health status, lifestyle factors and products previously used. The process is designed to support assessment of whether hair loss may be related to temporary shedding, scalp-related concerns, or genetic and hormonal factors.

Genetic and Hormonal Factors Included in Assessment

Male-pattern hair loss, also known as androgenetic alopecia, and female-pattern hair loss are commonly associated with genetic and hormonal factors. These conditions may appear before middle age. Early signs may include a gradually receding frontal hairline, thinning at the crown, finer hair strands or widening of the hair parting. Because these changes often develop gradually, early signs may be mistaken for stress, insufficient rest or unsuitable haircare products.

Dr. Leung Kin Hei, medical adviser to FastMed, said: "Hair loss can involve a range of underlying causes. General haircare products may help cleanse the scalp or improve hair appearance, but hair loss associated with genetic or hormonal factors requires a clearer understanding of hair loss type and possible causes. A structured assessment process can support more appropriate follow-up decisions."

Evidence-Informed Ingredient Information

FastMed's online consultation support may also provide medical information on commonly discussed ingredients for hair loss, based on assessment findings. For androgenetic alopecia, ingredients commonly referenced in medical literature and supported by regulatory approval include finasteride and topical minoxidil. Finasteride is the active ingredient in prescription medicines such as Propecia and Damocare, while topical minoxidil is commonly found in external hair growth products such as Regro and Regaine.

Suitability, method of use and potential risks vary across ingredients. Prescription medicines in particular should only be considered following medical assessment. FastMed's service is designed to support appropriate information provision and assessment-based follow-up, rather than product selection based solely on advertising, online reviews or brand claims.

Online Process Supports Privacy and Convenience

Hair loss is common, but concerns about appearance, confidence and privacy may delay medical support. FastMed's online process allows information to be submitted through a digital pathway before doctor assessment. Where appropriate following assessment, the platform may arrange relevant support, medication advice, delivery or follow-up.

Dr. Leung added: "Hair loss concerns may affect confidence, social interaction and emotional well-being. Medical support is not intended to create anxiety. A structured assessment process can help clarify possible causes, reduce reliance on unverified online information and support more informed follow-up decisions."

Hashtag: #FastMed  #Medical  #Health 

The issuer is solely responsible for the content of this announcement.

HONG KONG SAR - Media OutReach Newswire - 15 June 2026 - The Hong Kong Polytechnic University (PolyU) is committed to advancing knowledge transfer, encouraging students to embrace a spirit of innovation and entrepreneurship, address social challenges with professional knowledge and contribute to National development.

As the sole organising university of the inaugural Hong Kong Special Administrative Region (HKSAR) Contest of the 16th National E-commerce "Innovation, Creativity and Entrepreneurship" Competition for College Students (3Chuang Competition), PolyU hosted the HKSAR Contest cum Award Presentation Ceremony on 12 June. A total of 12 elite teams garnered 12 awards in the Contest, earning the opportunity to advance to the National Finals.

The inaugural HKSAR Contest of the 3Chuang Competition aims to encourage local tertiary students to break barriers across institutions, regions, cultures and disciplines. It brings together innovative ideas and unlocks entrepreneurial potential, further fostering the development of Hong Kong's innovation and technology ecosystem. Outstanding teams will have the chance to advance to the National Finals and expand their horizons.

In his speech, Prof. DONG Cheng, Associate Vice President (Knowledge Transfer) of PolyU, remarked, "PolyU is honoured to be the sole organiser of the inaugural HKSAR Contest of the 3Chuang Competition. We are committed to driving the translation of research outcomes into impact for societal benefits. The National competition provides a platform for young people to unlock their potential in innovation and entrepreneurship, bringing together remarkable talents, who can learn from each other with a creative mindset, serve society and contribute to National development." Prof. Dong added that PolyU had set up 15 translational research institutes and centres across the Chinese Mainland. He encouraged the winning teams to leverage PolyU's extensive innovation network, incubation support and market resources, thereby better integrating into the overall National development, tapping into Chinese Mainland markets, and converting innovation outcomes into tangible momentum for social advancement.

Prof. LI Qi, Chairman of the Competition Organizing Committee (COC) of the 3Chuang Competition from Xi'an Jiaotong University, has vigorously supported PolyU in hosting the HKSAR Contest and fully recognised its efforts. He remarked in his speech, "A total of 34 provinces, municipalities, autonomous regions and Special Administrative Regions across the Nation have taken part in this year's Competition, which also marks the HKSAR's debut participation. We especially appreciate the tremendous support and assistance from PolyU's senior management, faculty and students. They have contributed to the HKSAR and brought glory to the Nation, laying a fertile ground for nurturing '3Chuang' talents while connecting domestic and overseas stakeholders for the development of '3Chuang'. We warmly welcome outstanding teams from Hong Kong to the National Finals, to achieve even greater results."

The National 3Chuang Competition landed in Hong Kong last year. Since its kick-off, it has attracted numerous cross-region, cross-institution and cross-discipline teams to participate in the university-level round of competition. Team members come from 32 higher education institutions across Hong Kong, Macao, the Chinese Mainland and overseas. In addition to major universities in Hong Kong, prestigious names such as Guangdong University of Technology, Sun Yat-sen University, Shenzhen University, the City University of Macau and the University of Toronto in Canada also feature. Eventually, 29 outstanding teams from the Regular, International and Practical Tracks entered the HKSAR Contest, where they competed before a jury comprising experts from academia, industry and investment sectors for accolades including the First Prize, Second Prize and Best Entrepreneurship Award. The COC of the 3Chuang Competition will announce the list of teams who qualified for the National Finals after all provincial-level contests conclude later this month.

The winners of the HKSAR Contest of the 16th 3Chuang Competitionare as follows (the order of the teams winning the same award is arranged according to their names in Chinese):

MIAMI, June 15, 2026 (GLOBE NEWSWIRE) -- Defiance ETFs today announced the launch of the Defiance Daily Target 2X Long SpaceX ETF (Cboe: SPCU). SPCU begins trading today at 4am ET and seeks daily investment results, before fees and expenses, equal to 200% of the daily performance of SpaceX Class A common stock (NASDAQ: SPCX).

SpaceX priced its initial public offering at $135 per share and began trading on the Nasdaq on Friday, June 12, under the ticker SPCX. At that price, the company was valued at approximately $1.77 trillion, which according to reports ranks as the largest U.S. IPO in history by debut market value.

SPCU is purpose-built for active traders seeking magnified, short-term exposure to SpaceX. The Fund obtains its exposure primarily through swap agreements and/or listed options contracts rather than by holding SpaceX shares directly, allowing traders to express a high-conviction, tactical view on SpaceX in a single exchange-listed ticker, without a margin account and without managing options positions.

SPCU joins the Defiance Daily 2X Space ETF (Cboe: SPCL), which established 2X daily leveraged exposure to SpaceX on SpaceX's IPO date. On that date, SPCL's leveraged exposure was tied exclusively to SpaceX, although the Fund will hold other investments in accordance with its investment strategy and prospectus disclosures. SPCU further expands Defiance's lineup of leveraged products linked to SpaceX.

For full fund details, the prospectus, holdings, and performance current to the most recent month-end, visit defianceetfs.com/spcu or call 833.333.9383.

The Fund is not suitable for all investors. The Fund is designed to be utilized only by knowledgeable investors who understand the potential consequences of seeking daily leveraged (2X) investment results, understand the risks associated with the use of leverage, and are willing to monitor their portfolios frequently. The Fund is not intended to be used by, and is not appropriate for, investors who do not intend to actively monitor and manage their portfolios. The Fund pursues daily leveraged investment objectives, which means it is riskier than alternatives that do not use leverage. The Fund magnifies the performance of Space Exploration Technologies Corp. (the "Underlying Security") and is designed strictly for short-term use. For periods longer than a single day, the Fund's performance will be the result of compounded daily returns, which is very likely to differ from 200% of the return of SpaceX over the same period. It is possible that investors could lose their entire principal within a single trading day.

An investment in the Fund is not a direct investment in SpaceX.

About Defiance ETFs

Founded in 2018, Defiance is a leading ETF issuer specializing in thematic, income, and leveraged ETFs. Our first-mover leveraged single-stock ETFs empower investors to take amplified positions in high-growth companies, providing precise leverage exposure without the need to open a margin account.

Media Contact: Sylvia Jablonski | info@defianceetfs.com | 833.333.9383

IMPORTANT DISCLOSURES

Defiance ETFs LLC is the ETF sponsor. The Fund's investment adviser is Tidal Investments, LLC ("Tidal" or the "Adviser").

The Fund's investment objectives, risks, charges, and expenses must be considered carefully before investing. The prospectus and summary prospectus contain this and other important information about the investment company. Please read the prospectus and/or summary prospectus carefully before investing. Hard copies can be requested by calling 833.333.9383.

Investing involves risk. Principal loss is possible. As an ETF, the Fund may trade at a premium or discount to its net asset value ("NAV"). Shares are bought and sold at market price (not NAV) and are not individually redeemed from the Fund. Brokerage commissions and bid-ask spreads will reduce returns. A portfolio concentrated in a single theme or industry may be subject to a higher degree of risk. There is no guarantee the Fund's strategy will be successful, and an investor may lose some or all of their investment.

Leveraged Investment Risk. The Fund seeks daily investment results that correspond to two times (2X) the performance of its underlying portfolio. The use of leverage magnifies both gains and losses. As a result, the Fund may experience significant losses over short periods of time, including the potential loss of the entire investment within a single trading day. If the Target Portfolio's market value decreases by more than 50% on a given trading day, the Fund's investors could lose all of their money. The Fund may also be subject to the following risks:

Daily Reset and Compounding Risk. The Fund is designed to achieve its stated investment objective on a daily basis. Due to the effects of compounding, the Fund's returns over periods longer than one trading day will likely differ, and may differ significantly, from 200% of the performance of its underlying portfolio for the same period. This effect is more pronounced in volatile markets.

Short-Term Trading Risk. The Fund is intended for short-term trading and is not designed for long-term investment. Investors who hold shares for periods longer than a single trading day may experience returns that are substantially different from the Fund's stated objective. The Fund requires active monitoring and management.

Compounding and Market Volatility Risk. The Fund has a daily leveraged investment objective, and the Fund's performance for periods greater than a trading day will be the result of each day's returns compounded over the period, which is very likely to differ from two times (200%) the Target Portfolio's performance, before fees and expenses. The Fund will lose money if the Target Portfolio's performance is flat over time, and it is possible that the Fund will lose money even if the Target Portfolio's market value increases over a period longer than a single day. Due to daily rebalancing and the effects of compounding, the volatility of the Target Portfolio may affect the Fund's return as much as, or more than, the Target Portfolio's actual return. The impact of compounding will affect each shareholder differently depending on the period of time an investment in the Fund is held and the volatility of the Target Portfolio during that holding period.

Derivatives Risk. The Fund utilizes derivatives, including swap agreements and options contracts, to achieve its investment objective. Derivatives involve risks different from, and potentially greater than, those associated with direct investments in securities. These risks include increased volatility, imperfect correlation, liquidity constraints, valuation complexity, and the potential for losses exceeding the amount initially invested.

Counterparty Risk. The Fund is subject to counterparty risk through its use of derivatives. If a counterparty to a swap or other derivative instrument fails to meet its contractual obligations, the Fund may experience losses, delays in recovery, or reduced exposure.

Space Investing Risks. The Fund concentrates its exposure in companies involved in the space economy, including satellite communications, launch services, and space-enabled technologies. Companies involved in the design, manufacture, or launch of spacecraft, launch vehicles, or related systems face significant risks associated with launch failures, deployment malfunctions, mission delays, and cost overruns; space launches are inherently complex and costly, and failures may result in total loss of spacecraft or payloads, substantial financial losses, reputational harm, and increased regulatory scrutiny. Space-related businesses often rely on advanced, emerging, or unproven technologies and may be adversely affected by rapid technological change, engineering challenges, or competitors' development of superior or lower-cost technologies. The space industry is subject to extensive domestic and international regulation, including licensing requirements, export controls, national security restrictions, environmental regulation, and orbital debris mitigation standards; changes in laws or regulatory interpretations may increase compliance costs, delay operations, or limit deployment of space-based systems. Many space-focused companies depend on governmental or quasi-governmental customers and contracts, and reductions in government budgets, policy changes, or contract terminations could materially affect revenues. Space-based operations are exposed to risks from orbital debris, collisions, congestion in Earth's orbits, and space weather, any of which may damage satellites or spacecraft and result in service disruptions or complete mission failure. Many space-focused companies may have limited operating histories, depend on a narrow set of products or services, or rely on a small number of customers or missions. The Fund may have exposure to foreign issuers, including through ADRs, which can involve political instability, geopolitical tensions, trade restrictions, sanctions, and currency fluctuations that may disrupt supply chains or impair cross-border collaboration. When the Adviser determines there are insufficient Space Companies to meet the Fund's investment criteria, the Fund may obtain exposure to secondary space technology companies that support or enable space-related activities, which may be less directly exposed to the growth of the space economy and may be more sensitive to broader industry or market risks. The space industry is emerging and may experience higher volatility and uncertainty than more established industries.

Industry Concentration Risk. Because the Fund focuses on a specific theme and industry group, it may be more susceptible to adverse developments affecting that sector than a broadly diversified fund. The Fund will concentrate (i.e., invest 25% or more of its total assets) its investment exposure to companies in the space industry and in industries that develop, deploy, or operate space-related technologies and services.

IPO, SPAC, and De-SPAC Risk. The Fund may invest, including indirectly via derivative instruments, in securities of companies that have recently completed initial public offerings ("IPOs"), special purpose acquisition companies ("SPACs"), or companies that have become publicly traded through business combinations involving SPACs ("de-SPAC transactions"). These securities may be less seasoned, lack a meaningful trading history, have limited public information and research coverage, and involve risks similar to those of venture capital or other private equity investments. Their prices may be volatile, subject to speculative trading, and susceptible to rapid and substantial declines in value. SPACs are shell or blank check companies that raise capital in an IPO for the purpose of completing a business combination with a private operating company; there is no guarantee that a SPAC will complete a business combination or that any completed transaction will be successful. Conflicts of interest may arise among a SPAC's sponsors, affiliates, officers, directors, or promoters and unaffiliated security holders.

Swap Agreements. The use of swap transactions is a highly specialized activity, which involves investment techniques and risks different from those associated with ordinary portfolio securities transactions. Whether the Fund will be successful in using swap agreements to achieve its investment goal depends on the ability of the Adviser to structure such swap agreements in accordance with the Fund's investment objective and to identify counterparties for those swap agreements.

Non-Diversification Risk. The Fund is classified as non-diversified, which means it may invest a larger percentage of its assets in a smaller number of issuers. As a result, the Fund's performance may be more volatile and more sensitive to the performance of individual holdings.

Equity Securities Risk. Investments in equity securities are subject to market risk, including the potential for significant price fluctuations due to company-specific events, broader market conditions, economic developments, and changes in investor sentiment.

Foreign and ADR Risk. To the extent the Fund has exposure to foreign issuers or American Depositary Receipts (ADRs), it may be subject to additional risks, including currency fluctuations, political and economic instability, differing regulatory standards, and reduced liquidity.

Small- and Mid-Capitalization Risk. The Fund may invest in small- and mid-cap companies, which may be more volatile, less liquid, and more sensitive to economic changes than larger companies.

Liquidity Risk. In certain market conditions, the Fund's investments or derivative instruments may become less liquid, making it difficult to adjust exposure or achieve the desired investment objective. Reduced liquidity may also lead to wider bid-ask spreads for Fund shares.

Rebalancing Risk. The Fund seeks to rebalance its exposure daily to maintain its target leverage. If the Fund is unable to rebalance effectively due to market disruptions, liquidity constraints, or operational issues, its exposure may deviate from its intended objective.

Tracking and Correlation Risk. There is no guarantee that the Fund will achieve a high degree of correlation to 200% of the daily performance of its underlying portfolio. Market volatility, fees, transaction costs, and derivative pricing may cause performance to deviate from expectations.

High Portfolio Turnover Risk. The Fund's strategy involves frequent trading and daily rebalancing, which may result in high portfolio turnover, increased transaction costs, and potentially higher taxable distributions.

Tax Risk. The Fund intends to qualify for favorable tax treatment as a regulated investment company (RIC), but there is no guarantee it will do so. Distributions may be taxable as ordinary income, capital gains, or a combination of both.

New Fund Risk. The Fund is recently organized and has limited operating history. As a result, there is limited performance history for investors to evaluate.

Market and Economic Risk. The value of the Fund's investments may decline due to general market conditions, economic trends, geopolitical events, interest rate changes, inflation, or other external factors beyond the control of the Fund.

Brokerage commissions may be charged on trades.

Distributed by Foreside Fund Services, LLC.

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Copyright 2026 GlobeNewswire, Inc.

This recognition establishes a new global benchmark for disaster preparedness and humanitarian logistics, creating a scalable model for vulnerable coastal regions worldwide.

BATANGAS CITY, PHILIPPINES - Media OutReach Newswire - 15 June 2026 - Global trade enabler DP World today announced that its Batangas Integrated Port (BIP) is now the world's first READY Port, establishing a new benchmark for disaster preparedness and humanitarian logistics.

READY Port (Resilience, Emergency Action, and Disaster-ready) is a global capacity-strengthening programme advocated by the UN Logistics Cluster, established to strengthen disaster readiness of ports to enable humanitarian resiliency of countries during emergencies.

As climate-related disasters and supply chain disruptions increase globally, the READY Port framework offers a scalable model for enhancing the resilience of critical logistics infrastructure. The Philippines was selected as the pilot location for the initiative due to its exposure to climate-related risks and natural disasters. Bringing together key public and private sector stakeholders, as well as local and international humanitarian organisations, READY Port establishes a coordinated and resilient emergency response ecosystem anchored on seaports and logistics hubs.

The designation follows the completion of a three-day, multi-stakeholder READY Port workshop in partnership with the World Food Programme (WFP) Philippines at Batangas Port, where government agencies, humanitarian organisations and private-sector partners assessed emergency response capabilities, reviewed operational protocols and participated in scenario-based exercises to strengthen crisis preparedness.

BIP is operated by DP World's local partner, Asian Terminals Inc. (ATI) and serves as a critical gateway for the Philippines, offering comprehensive capabilities for international and domestic cargoes, rolling cargoes, passenger movements, and direct connectivity to nearby islands and key destinations across the Visayas and Mindanao.

Insights from the workshop have been consolidated into a Port Readiness Action Plan to help strengthen strategic frameworks for future implementation of capacity-building initiatives across ports in the Philippines and around the world.

Glen Hilton, CEO & Managing Director, Asia Pacific, DP World, said: "We are honoured that the Batangas Integrated Port is now the world's first READY port. This collaboration with WFP and our partners reflects our shared commitment to building resilient port infrastructure that serves not only as gateways for trade, but also as vital lifelines for communities during times of crisis. By leveraging DP World's integrated ports and logistics capabilities through ATI, our local partner in the Philippines, and across our global network, we are strengthening preparedness and ensuring that humanitarian assistance can move swiftly and efficiently in support of disaster response, national recovery efforts, and community resilience."

Manuel Cabochan III, Department of Transportation Assistant Secretary for Special Concerns, said: "Disaster preparedness is not only the responsibility of one government agency alone. It requires a whole-of-government and whole-of-society approach where national agencies, port operators, logistics providers, humanitarian organizations, local government units, and development partners work together towards a common goal. This underscores the importance of READY Port as we come together to prepare through planning, capacity building, and information sharing, and ultimately develop strong mechanisms to ensure continuity of ports and logistics operations during emergencies. We commend the World Food Programme, DP World, and the Logistics Cluster for pioneering this initiative."

Joao Dos Santos Merencio, World Food Programme Head of Supply Chain in the Philippines, said: "WFP is committed to supporting this initiative by fostering coordination, sharing humanitarian experience, and working closely with all stakeholders to align port readiness efforts with national disaster preparedness frameworks. The READY Port initiative brings together port authorities, national government agencies, the private sector, and the humanitarian community as one cohesive support unit. This framework helps ensure that ports continue to operate effectively under crisis conditions while prioritizing humanitarian cargoes when it matters most."

About DP World

DP World is reshaping the future of global trade to improve lives everywhere. Operating across six continents with a team of over 125,000 employees, we combine global infrastructure and local expertise to deliver seamless supply chain solutions. From Ports and Terminals to Marine Services, Logistics and Technology, we leverage innovation to create better ways to trade, minimizing disruptions from the factory floor to the customer's door.

In Asia Pacific, DP World employs over 11,000 people across 22 geographies. We operate 17 ports and terminals, complemented by a comprehensive suite of end-to-end supply chain solutions - to connect the region to the rest of the world.

WE MAKE TRADE FLOW

The issuer is solely responsible for the content of this announcement.

Hashtags: #DPWORLD

Supported by the diamond industry's largest marketing budget in 15 years, Desert diamonds Icons will launch ahead of the end of year holiday season and build on the Desert diamonds campaign's success in driving natural diamond desire

LAS VEGAS, US - Media OutReach Newswire - 15 June 2026 - At the annual JCK Las Vegas Show - the largest jewellery event in the global calendar ? De Beers Group today set out its view on the way forward for the natural diamond sector, calling on the trade to work together to capitalise on the early success of the Desert diamonds 'beacon' campaign with the introduction of Desert diamonds Icons.

The Desert diamonds beacon campaign launched in late 2025 and has already succeeded in shaping consumer demand for both natural diamonds in general and coloured diamonds in particular, with natural diamond sales at US independents increasing 4% in Q4 2025 and 9% in Q1 2026, while those in the K to Z colour range have seen even stronger growth, up 15% in Q4 2025 and 19% in Q1 2026.

Following the launch of Desert diamonds Bridal earlier this year, Desert diamonds Icons will focus on bringing a sense of newness and individuality to four iconic jewellery design classics - stud earrings, the eternity band, the tennis bracelet and the halo pendant - which between them comprise 70% of diamond jewellery acquisitions. Launching in September, the campaign will include training and marketing support for all retailers.

During a keynote presentation, De Beers Group executives stated that while demand has performed well for larger natural diamonds and this has supported stable retail sales value for natural diamond jewellery, it is critical for industry participants to work together on the campaign to drive demand across the natural diamond category as a whole.

With the campaign benefitting from the diamond industry's biggest natural diamond marketing budget in 15 years, Desert diamonds is expected to deliver enhanced retail impact in 2026, based on a range of positive data points from its initial run. Growth in natural diamond desirability, online searches for natural diamonds, and increased coloured natural diamond sales across independent jewellers all highlight that the momentum behind the campaign is building. Noting that the 2026 campaign run will also benefit from a geo-targeting approach that directs consumers to specific retailers carrying Desert diamonds, De Beers executives encouraged the entire trade to support the fast-growing trend by stocking Desert diamonds Icons products and by signing up to Promoboxx to access marketing materials and participate in geo-targeting.

The presentation also included a summary of key consumer and industry insights published today in The Diamond Report, highlighting how commercial dynamics are evolving at pace for US jewellery retailers as the synthetic lab-grown diamond sector matures while consumer interest in natural diamonds grows.

Speaking at the presentation, Al Cook, CEO of De Beers Group, said: "Consumer desire for natural diamonds is strong - but we need to work together as an industry in support of Desert diamonds to unlock the full value of the opportunity. The results from the campaign's initial run demonstrate how it is already stimulating demand, and with Desert diamonds Icons we are doubling down at a critical moment.

"The jewellery retail landscape is evolving at pace. With the sustained falls in price of synthetic lab-grown diamonds, and large falls in demand for larger synthetic lab-grown diamonds, there may be challenges ahead for retailers who focus on synthetic lab-grown diamonds."

"However, with challenge comes opportunity, and the growing success of the Desert diamonds campaign is evident. As we head into the campaign's second year, with the industry supported by the largest category marketing budget in 15 years, the natural way forward is clear to see."

De Beers Group also reported in its presentation how collaboration continues deliver progress in other areas, with GIA's purchase of an equity share in Tracr supporting the platform's path to independence and providing the potential for it to scale faster across the sector. Meanwhile, the Natural Diamond Council has put in place a compelling new strategy on the back of its growing budget, as more diamond producing countries and trade bodies have provided funding, and will introduce a new natural diamond trust mark to support consumer confidence through visible differentiation between natural diamonds and synthetic lab-grown diamonds.

Notes to editors

Desert diamonds marketing materials are available to download here

The Diamond Report is available to download here

About De Beers Group

Established in 1888, De Beers Group is the world's leading diamond company with expertise in the exploration, mining, marketing and retailing of diamonds. Together with its joint venture partners, De Beers Group employs more than 20,000 people across the diamond pipeline and is the world's largest diamond producer by value, with diamond mining operations in Botswana, Canada, Namibia and South Africa. Innovation sits at the heart of De Beers Group's strategy as it develops a portfolio of offers that span the diamond value chain, including its jewellery houses, De Beers London and Forevermark, and other pioneering solutions such as diamond sourcing and traceability initiatives Tracr and GemFair. De Beers Group also provides leading services and technology to the diamond industry in the form of education and laboratory services and a wide range of diamond sorting, detection and classification technology services. De Beers Group is committed to 'Building Forever,' a holistic and integrated approach to sustainability that underpins our efforts to create meaningful impact for the people and places where our diamonds are discovered. Building Forever focuses on three key areas where, through collaborations and partnerships around the globe, we have an enhanced ability to drive positive impact; Livelihoods, Climate and Nature. De Beers Group is a member of the Anglo American plc group. For further information, visit www.debeersgroup.com.

The issuer is solely responsible for the content of this announcement.

Hashtags: #NaturalDiamonds #Diamonds #Dessertdiamonds #DeBeersGroup #JCK

ZW191 demonstrates compelling anti-tumor activity in platinum-resistant ovarian cancer patients regardless of FRα expression level

Confirmed objective response rate (cORR) of 78.6% in FRα-positive (≥75% at PS2+) platinum-resistant ovarian cancer patients and 47.4% in FRα-negative patients (<75% at PS2+) across all dose levels studied

Median duration of response was not reached at the time of data cutoff, and median progression-free survival was 7.6 months across ovarian and endometrial cancer cohorts

Patient recruitment in dose optimization cohorts completed, with favorable tolerability profile and broad therapeutic window supporting continued clinical development

VANCOUVER, British Columbia, June 14, 2026 (GLOBE NEWSWIRE) -- Zymeworks Inc. (Nasdaq: ZYME), a biotechnology company managing a portfolio of licensed healthcare assets while developing a diverse pipeline of novel, multifunctional biotherapeutics, today presented new clinical data from the dose-escalation portion of its ongoing Phase 1 study evaluating ZW191, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), at the European Society for Medical Oncology (ESMO) Gynaecological Cancers Congress 2026.

The presentation highlights compelling anti-tumor activity in patients with platinum-resistant ovarian cancer (PROC) and in patients with endometrial cancer, including patients with both positive and negative FRα expression. The results further support the potential of ZW191 to address limitations of currently available and investigational FRα-targeted therapies and broaden treatment opportunities for patients with gynecologic cancers.

"We are highly encouraged by these data, which continue to demonstrate the differentiated profile of ZW191 and its potential to deliver meaningful clinical benefit across a broad population of patients with ovarian and endometrial cancers," said Sabeen Mekan, M.D., Senior Vice President and Chief Medical Officer of Zymeworks. "The response rate observed in FRα-positive ovarian cancer patients compares favorably with currently available therapies, while maintaining meaningful activity in patients with negative FRα expression. Together these encouraging data on durability, progression-free survival, and manageable safety profile further strengthen our confidence in the program and reinforce the ability of our ADC platform to generate differentiated therapeutics."

The analysis included efficacy data by FRα expression level from Part 1 of the ongoing Phase 1 study as of the March 9, 2026, data cutoff. FRα expression was assessed by immunohistochemistry and categorized using the Proportion and Staining Intensity, defined as the percentage of cells with 2+/3+ staining. Tumors were categorized as FRα-negative (<75%) or FRα-positive (≥75%).

Key Findings

Among response-evaluable PROC patients, ZW191 demonstrated a cORR of 78.6% in patients with FRα-positive tumors and 47.4% in patients with FRα-negative tumors across all dose levels. Disease control rates were 100.0% and 89.5%, respectively. Confirmed ORR in the overall PROC population was 58.8% across all dose levels studied and 65.2% in dose range of 6.4-9.6 mg/kg. These findings demonstrate meaningful anti-tumor activity across both FRα-positive and FRα-negative tumors as well as in the overall population.

In endometrial cancer patients with FRα-negative tumors, ZW191 demonstrated a cORR of 40.0% and a disease control rate of 80.0% across all doses evaluated.

Across both ovarian and endometrial cancer cohorts, responses were observed early and continued to deepen over time. Median duration of response was not reached at the time of data cutoff, and median progression-free survival was 7.6 months.

ZW191 continued to demonstrate a favorable tolerability profile. Treatment-emergent adverse events (TEAEs) occurred in 98% of patients, with grade ≥3 TEAEs reported in 55% of patients. The most common grade ≥3 adverse events were neutropenia (24%), anemia (20%), and thrombocytopenia (12%). Serious TEAEs occurred in 35% of patients, and 20% of patients discontinued treatment due to adverse events. Overall, the safety profile was manageable and consistent with continued clinical development.

"These results further demonstrate the potential of ZW191 to provide meaningful clinical benefit for patients with difficult-to-treat gynecologic cancers," said Kosei Hasegawa, M.D., Ph.D., Saitama Medical University International Medical Center and presenting author. "The robust activity observed in FRα-positive ovarian cancer, together with encouraging responses in tumors with lower FRα expression, suggests ZW191 could expand the benefit of FRα-targeted therapy to a broader patient population."

Part 2a, the dose optimization portion of the Phase 1 study evaluating ZW191 in ~60 PROC patients randomized to either 6.4 mg/kg every three weeks or 9.6 mg/kg every three weeks, has completed enrollment. Data from Part 2a will be presented at a future medical meeting and are expected to inform dose selection for potential future development.

ZW191's differentiated profile, including its novel FRα-targeting antibody, ZD06519 payload, and high drug-to-antibody ratio, supports its potential to address key limitations of current therapies and broaden the applicability of FRα-targeted treatment approaches across multiple tumor types.

About ZW191

ZW191 is an antibody-drug conjugate engineered to target a protein called folate receptor-⍺ found in ~75% of high-grade serous ovarian carcinomas1, over 50% of endometrial cancers2,3 and ~70% of lung adenocarcinomas4. ZW191's differentiated design strongly supports its ability to internalize into FR⍺-expressing cells with the potential to release bystander active topoisomerase-1 inhibitor (ZD06519), a novel proprietary payload developed by Zymeworks to kill tumor cells.

About Zymeworks Inc. 

Zymeworks is a global biotechnology company managing a portfolio of licensed healthcare assets and developing a diverse pipeline of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases, including cancer, inflammation, and autoimmune disease. Zymeworks' asset and royalty aggregation strategy focuses on optimizing positive future cash flows from an emerging portfolio of licensed products such as Ziihera (zanidatamab-hrii) and other licensed products and product candidates, such as pasritamig. In addition, Zymeworks is also building a portfolio of healthcare assets that can generate strong cash flows, while supporting the development of innovative medicines. Zymeworks engineered and developed Ziihera, a HER2-targeted bispecific antibody using Zymeworks' proprietary Azymetric technology and has entered into separate agreements with BeOne Medicines Ltd. (formerly BeiGene, Ltd.) and Jazz Pharmaceuticals Ireland Limited granting each exclusive rights to develop and commercialize zanidatamab in different territories. Zymeworks is rapidly advancing a robust pipeline of product candidates, leveraging its expertise in both antibody drug conjugates and multispecific antibody therapeutics targeting novel pathways in areas of significant unmet medical need. Zymeworks' complementary therapeutic platforms and fully integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly differentiated antibody-based therapeutics. These capabilities have been further leveraged through strategic partnerships with global biopharmaceutical companies. For information about Zymeworks, visit www.zymeworks.com and follow @ZymeworksInc on X.

Contacts:

Investor Inquiries:

Shrinal Inamdar

Vice President, Investor Relations

(604) 678-1388

ir@zymeworks.com   

Media Inquiries:

Diana Papove

Vice President, Corporate Communications

(604) 678-1388

media@zymeworks.com

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1 K?bel, M., Madore, J., Ramus, S. et al., Br J Cancer 111, 2297?2307 (2014).

2 May B, Conway N, Truong T, Linhart S, et al. FRα, B7-H4, & HER2 Expression in Endometrial Cancer: Assessing the Promise of Antibody Drug Conjugate Therapies. Presented at: SGO 2025 Winter Meeting; January 30 - February 1, 2025; Whistler, British Columbia, Canada.

3 Senol S, Ceyran AB, Aydin A, Zemheri E, Ozkanli S, K?semetin D, Sehitoglu I, Akalin I. Folate receptor α expression and significance in endometrioid endometrium carcinoma and endometrial hyperplasia. Int J Clin Exp Pathol. 2015 May 1;8(5):5633-41.

4 O'Shannessy DJ, et al., Oncotarget. 2012 Apr; 3(4):414-25.

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